Agios Kassianos Church, also known as Ayios Kassianos, is in Nicosia, Cyprus. It is dedicated to Saint Kassianos, a martyr and a 4th-century Christian saint. He is also known as Saint Cassian of Imola or Saint Cassian of Rome. The church is believed to have been built in the 18th century, but it might have been constructed on the site of an earlier, possibly Byzantine-era church.

Saint Kassianos, also known as Saint Cassian of Imola or Saint Cassian of Rome, was a Christian martyr and saint from the 4th century. He was a schoolmaster in Imola, a town in present-day Italy, who was arrested and persecuted during the reign of Emperor Julian the Apostate for his Christian faith.

The story of Saint Kassianos' martyrdom is both tragic and inspiring. When he refused to renounce his Christian faith, he was sentenced to a slow and painful death. His captors tied him to a stake and left him to be killed by his students, armed with iron styluses, the sharp writing instruments used at the time. Despite the excruciating pain, Saint Kassianos remained steadfast in his faith until his death.

Saint Kassianos' story of unwavering devotion and commitment to Christianity in the face of persecution has inspired many believers over the centuries. His feast day is celebrated on August 13th in the Western Christian tradition and February 29th in the Eastern Orthodox Church.

The church was built by the Greek Orthodox community of Nicosia, and as such, it reflects the religious and cultural heritage of the city.

The division of Nicosia, which occurred in 1963 and solidified in 1974, has profoundly impacted the city's religious sites, including Agios Kassianos Church. The church is located in the southern, Greek Cypriot-administered part of Nicosia, and it has likely faced challenges in terms of accessibility and maintenance due to the city's division. Nonetheless, it remains an important place of worship and spiritual significance for the local community.